The Effect of Oxidative Stress Genes on the Response to Anti-TNF Therapy in Patients with Crohns’ Disease

Oxidative stress is defined as a disruption of the balance between production of reactive oxygen species and the body’s ability to fight them off. They contribute to many autoimmune diseases, which have in the past been treated with anti-TNF therapy using inhibitors of said cytokine. So far, research has shown, that anti-TNF therapy lowers oxidative stress in patients with Crohn’s disease, but little is known about the effect of oxidative stress genes in the response to anti-TNF therapy. In our study, we focused on the effect of two genes, associated with oxidative stress, SOD2 and CAT, and found, that a higher expression of these genes is linked to a better long term response to treatment with the anti-TNF drug adalimumab.

Category: MEDICINE Country: SLOVENIA Year: 2020


Aleks Brumec