Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by motor neuron death in the brain and spinal cord. Though cell death in ALS is poorly understood, scientists believe that apoptosis and autophagy play a role. The MAP4K4 kinase regulates these and its inhibition has slowed ALS in ALS-derived Induced pluripotent stem cells, iPSCs. This project examines the pathogenesis of ALS cell death, highlights that inhibiting the MAP4K4 kinase can rescue motor neurons, designs a method for this investigation in vivo, and examines the viability of the treatment.

Category: MEDICINE Country: LUXEMBOURG Year: 2020


David Emanuel Lawyer

Etienne André Leroy

Sarah Mackel