16 Jul MODELLING TREATMENT FOR ALS

Posted at 12:00h in 2020, Luxembourg, Medicine by

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by motor neuron death in the brain and spinal cord. Though cell death in ALS is poorly understood, scientists believe that apoptosis and autophagy play a role. The MAP4K4 kinase regulates these and its inhibition has slowed ALS in ALS-derived Induced pluripotent stem cells, iPSCs. This project examines the pathogenesis of ALS cell death, highlights that inhibiting the MAP4K4 kinase can rescue motor neurons, designs a method for this investigation in vivo, and examines the viability of the treatment.

Category: MEDICINE — Country: LUXEMBOURG — Year: 2020

 


David Emanuel Lawyer


Etienne André Leroy


Sarah Mackel

 

 

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