Development of a new, multicellular network model of the epithelial-mesenchymal transition (EMT) and finding a new potential drug target by building hybrid EMT in the model

Epithelial-mesenchymal transition (EMT) contributes to the development of cancer metastases. Our research group built a new, multicellular network model of the process in order to find new possible drug-targets for the abrogation of metastases. My aim was to find a possible drug-target for the treatment of hybrid EMT cells. This phenotype was built in the model and cell-cell simulations were run. A protein has been found, which made the cell lose its invasive properties after being inhibited. This means that a new, possible drug-target has been found for the treatment of cancer metastases.

Category: MEDICINE Country: HUNGARY Year: 2021

 

Erik Seitz